Polymorphisms of xenobiotic metabolism enzyme genes cyp2e1, gstm1, gstt1, ephx1 as biomarkers of sensitivity to exposure to water disinfection byproducts (using chloroform as an example)

Chloroform accumulation in the body and increase its steady-state concentrations blood of exposed people have been established to be associated with polymorphisms enzyme genes a genotype involved metabolism water disinfection byproducts (A415G EPHX1 gene, C1091T CYP2E1 zero mutations GSTT1 GSTM1 genes) (р < 0.000001). These correlate higher chloroform levels consuming chlorinated drinking water: by 43.8 % for gene polymorphism; 68.2 GSTT1; 80.4 0.01). genetic polymorphism makes much more probable (levels ≥ Р75), which is most pronounced when combined GSTТ1 polymorphism. The study results allow us consider hetero- homozygous polymorphic genotypes AG/GG CT/TT null allele as predisposition factors body. This increases probability health outcomes chronic exposure this byproduct. A415G alleles their combinations including combination and/or can used informative biomarkers sensitivity assessing risks trihalomethanes (chloroform) at not exceeding MPC water.